… -old 3xTgAD mice, led to an elevation in serum ketone body levels, … Effects of a dietary
ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids …

… approaches that produce ketone bodies for energy metabolism, … , 5xFAD mice fed a 4-month
KD had reduced hippocampal Aβ … 3xTg-AD mice fed an 8-month 43.5% carbohydrate diet …

… , including amino acids, ketone bodies (KB), and fatty acids [30,… In 3xTgAD mice, KE had no
effect on ATP hydrolysis in the … shifting to mitochondrial respiration over glycolysis [121,122]. …

… for ketone body generation from fatty acids and amino acids [… two AD mouse models, ie,
APP/PS1 and 3xTg-AD, EAAT2 … impaired glycolysis and TCA cycle, all of which adversely impact …

… ), APP/PS1 mice, 3xTg-AD (triple-transgenic mouse model … of ketone bodies and has a
lasting cognition-improving effect in … bypass of the glycolytic pathway [86, 173, 188]. In the brain, …

… and promoted glycolysis and tricarboxylic acid (TCA) cycle, and … in hippocampus regions of
mice of the control, model, and … contents of 4 intermediate metabolites in the TCA cycle in the …

… diseases such as Alzheimer’s disease. This decreased … a reduction of several glycolysis
intermediates in the … enhancing levels of circulating ketone bodies, KD usually lacks …

… and moderate protein diets that induce the production of ketone bodies through fat … -β-hydroxybutyrate
treatment in the 3xTgAD mouse model enhances energy use in the hippocampus …

… safe ketone body precursors for the treatment of diseases in … of energy metabolism/glycolysis
and nucleotide, protein, as well as … For example, hippocampal upregulation of miR-181 and …

… matrix for beta-oxidation and ketone body synthesis. As part of … occurred in the hippocampus
of APP/PS1 AD model mice [84]. … glycolysis has been shown to improve PD symptoms in …